2. Answer: E. In Parkinson disease, loss of dopamine enhances the effects of the indirect basal ganglia pathway, which is also driven by cholinergic neurons intrinsic to the striatum. A muscarinic blocker will reduce the stimulatory effects of ACh on the indirect pathway.
3. Answer: D. The patient suffers from hemiballismus, which affects the neurons in the subthalamic nucleus.
Answer: A. The caudate nucleus is a major site of degeneration in Huntington disease.
Figure IV-10-3. The Six-Layered Neocortex
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