Aorticopulmonary Septum

NeuraJ crest ceUsrnigrate into the truncal and bulbar ridges, which grow in a spiral fashion and fuse to form the aorticopulmonary (AP) septum. The AP septum divides the truncus arteriosus into the aorta and pulmonary trunk (Figure III-2-9).

Figure 111-2-9. Formation of the Aorticopulmonary Septum

Clinical Correlate

Transposition of the great vessels occurs when the AP septum fails to develop in a spiral fashion and results in the aorta opening into the right ventricle and the pulmonary trunk opening into the left ventricle. This causes right-to-left shunting of blood with resultant cyanosis,

Infants born alive with this defect must have other defects that allow mixing of oxygenated and deoxygenated blood,

Figure 111-2-9. Formation of the Aorticopulmonary Septum

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