The zona pellucida must degenerate for implantation to occur.
The blastocyst usually implants within the posterior wall of the uterus.
The embryonic pole of blastocyst implants first.
The blastocyst implants within the functional layer of the endometrium during the progestational phase of the menstrual cycle.
The trophoblast differentiates into the cytotrophoblast and syncytiotrophoblast.
Fertilization occurs in the ampulla of the uterine tube with the fusion of the male and female pronuclei to form a zygote. During the first 4-5 days of the first week, the zygote undergoes rapid mitotic division (cleavage) in the oviduct to form a morula before entering the cavity of the uterus. A blastocyst forms as fluid develops in the morula, resulting in a blastocyst that consists of an inner cell mass known as the embryoblast (becomes the embryo) and the outer cell mass known as the trophoblast (becomes the placenta). At the end of the first week, the trophoblast differentiates into the cytotrophoblast and syncytiotrophoblast and then implantation begins.
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