Contents

Preface vii

I. BASIC TUMOR IMMUNOLOGY

1. Antigen Processing and Presentation 3 laubence c. eisenlohr and jay l. rothstein

2. Antigen Recognition and T-Cell Biology 37

michael i. nishimura, Jeffrey j. roszkowski, tamson v. moore, natasha brasic, mark d. mckee, and timothy m. clay

3. Mechanisms of Tumor Evasion 61

michael campoli, soldano febbone, abnold h. zea, paulo c. rodríguez, and augusto c. ochoa

4. Tumor Antigens and TumorAntigen Discovery 89 daniel f. graziano and olivera j. finn

II. CANCER VACCINE DEVELOPMENT

5. Peptide Vaccines against Cancer 115

jay a. bebzofsky, sangkon oh, and masaki terabe

6. DNA Vaccination in Immunotherapy of Cancer 137

andrew y. choo, daniel k. choo, j. Joseph kim, and david b. weineb

7. Antibody Inducing Polyvalent Cancer Vaccines 157 govind ragupathi, john gathubu, and philip Livingston

8. Dendritic Cell-based Vaccines for Cancer Therapy 181 a. gbolleau, a. sloan, and j.j. mulE

9. Undefined-antigen Vaccines 207 hong-ming hu, yiwei chu, and walteb j. ubba

10. Cancer Vaccines in Combination with Multimodality Therapy 227 leisha a. emens, b. todd beilly, and elizabeth m. jaffee

III. VACCINE-ENHANCING STRATEGIES

11. Cytokine Therapy for Cancer: Antigen Presentation 249 sameek roychowdhury and michael a. caligiuri

12. Tinkering with Nature: The Tale of Optimizing Peptide Based Cancer Vaccines 267

olivier michielin, jean-sebastien blanchet, theres fagerberg, danila valmori, verena rubio-godoy, daniel speiser, maha ayyoub, pedro alves, immanuel luescher, jean-edouard gairin, jean-charles cerottini, and pedro romero

13. Adoptive Cellular Immunotherapy of Cancer: A three-signal paradigm for translating recent developments into improved treatment stategies 293 shawn m. jensen and Bernard a. fox

IV. CLINICAL TRIALS DESIGN

14. Clinical Trial Designs for Therapeutic Cancer Vaccines 339 richard simon

15. Clinical Trial Design and Regulatory Issues for Therapeutic Cancer Vaccines 351

jan casadei, howard z. streicher, and jay j. greenblatt

16. Immune Monitoring 369

paul j. mosca, timothy m. clay, michael a. morse, and h. kim lyerly

Index 389

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