Antigen Presentation

Two pathways of antigen presentation, either "direct" or "indirect", have been proposed in alloantigen recognition [55]. Donor APC can present antigen to host T cells via the direct pathway, thereby inducing a strong immune response. The emigration of antigen presenting dendritic cells with upregulated MHC-class-II molecules from the donor cornea into the host tissue has recently been shown in the mouse model of corneal transplantation [15,32]. On the other hand, host APC are able to present corneal alloantigens via the indirect pathway of antigen presentation. The direct pathway is a specific feature of the response towards alloantigens, whereas the indirect pathway represents the "normal" mechanism for the generation of an immune response. Even when the indirect pathway is considered less effective, experimental studies have shown that it may result in prompt corneal graft rejection [33].

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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