Class II HLA

Class II HLA molecules were serologically defined as HLA-DP, HLA-DQ and HLA-DR. They are composed of alpha and beta chains, both coded for by genes in the MHC. The beta chains are generally more heterogeneic; in fact, in some cases there is only one HLA alpha chain for a given Class II HLA type, in which case variations in the beta chain alone confer differences in subtypes and peptide binding repertoires. The class II HLA molecules are normally found primarily on antigen presenting cells such as dendritic cells, B cells and macrophages. During an inflammatory response other cell types may be induced to express Class II HLA antigens, including retinal pigment epithelial cells and vascular endothelial cells. Unlike class I MHC molecules, the binding cleft formed by the alpha and beta chains of Class II MHC molecules is open at both ends,allowing presentation of peptides containing 12-24 amino acids. The peptides bound to class II molecules are usually derived from proteins found in the extracellular fluid. The Class II molecules and peptide interact primarily with T-cell receptors on CD4+ lymphocytes.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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