Once a potential target is identified, researchers must then find a compound which best interacts with the target. With techniques like high-throughput screening, the interactions of thousands of compounds with the disease target may be tested extremely rapidly via computers and automated mechanisms. Out of this operation, different compounds are identified for their capacity to bind to the identified target. These compounds are called "leads." In order to become a drug candidate a lead needs to be modified to improve its pharmacokinetic properties.
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