Toxicogenomics Databases

Comparative Toxicogenomics Database. Mount Desert Island Biological Lab. URL: http://www.niehs.nih.gov/oc/factsheets/ ctd.htm. One of the greatest challenges for comparative toxicogenomics is the integration of the vast amount of genomic information being generated for a variety of model organisms. At present, there are several disparate but complementary databases on genomic sequences. Most of these databases provide data on gene and genome sequences for individual animal species. The ability to assess and develop proteomic tools for the study of cancer will enable both the FDA and NCI to better understand the promises and limitations of proteomics. Proteo-mics will undoubtedly impact both the ability of scientists to detect cancer earlier than ever before and allow clinicians to truly tailor therapy.

GeneCards. Weizmann Institute, Israel. URL: http://www. genecards.org/. An integrated database of human genes that includes genomic, proteomic, and transcriptomic information, and orthologies, disease relationships, SNPs, gene expression, and gene function.

Online Mendelian Inheritance in Man (OMIM). NCBI. URL: http://www.ncbi.nlm.nih.gov/omim/. A catalog of human genes and genetic disorders authored and edited by Dr. Victor A. McKusick and his colleagues at Johns Hopkins and elsewhere, and developed for the World Wide Web by NCBI, the National Center for Biotechnology Information. The database contains textual information and references. It also contains copious links to MEDLINE and sequence records in the Entrez system, and links to additional related resources at NCBI and elsewhere.

Signal Transduction Knowledge Environment (STKE). Science Magazine, AAAS. URL: http://stke.sciencemag.org/. A weekly electronic journal on cell signaling.

UK BioBank. Dept of Health, Medical Research Council, Wellcome Trust. URL: http://www.ukbiobank.ac.uk/. Aims to build a major resource to support a diverse range of research that will in turn improve the prevention, diagnosis, and treatment of illness and the promotion of health throughout society. The project will follow the health of a large group of volunteers for many years, collecting information on environmental and lifestyle factors and linking these to medical records and biological samples. The samples will be stored so that they can be used for biochemical and genetic analysis in the future.

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