Membranous Glomerulonephritis




Imaging Gross Pathology Micro Pathology



A 5-year-old white male presents with generalized edema and abdominal distention, producing respiratory embarrassment.

The child had a URI one week ago.

VS: normotension. PE: generalized pitting edema; free ascitic fluid in peritoneal cavity; shifting dullness and fluid thrill present; normal funduscopic exam.

UA: 4+ proteinuria (> 3 g/24 hours). Hypoalbuminemia; hypercholesterolemia; hypertriglyceridemia; decreased serum ionic calcium; normal C3 levels; moderately elevated serum creatinine and BUN.

Kidneys slightly enlarged, soft, and yellowish.

Light microscopy and immunofluorescent studies normal on renal biopsy (no evidence of immune complex deposition).

Corticosteroids; salt-restricted diet; diuretics; electrolyte therapy and monitoring.

Also called lipoid nephrosis, it is the most common cause of idiopathic nephrotic syndrome in children and is associated with infections or vaccinations. Good prognosis. P-250


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