Chapter Summary continued

Follicular lymphomas are the most common form of non-Hodgkin lymphoma in the United States and are all derived from B cells. They tend to present with diffuse disease and have a better prognosis than diffuse lymphomas.

Diffuse large Ekell lymphoma is an aggressive, rapidly proliferating tumor that may be present at extranodal sites and may be associated with EBV or HHV-8 infection.

Small nondeaved lymphoma (Burkitt lymphoma) occurs in African type with jaw involvement and American type with involvement of the abdomen. Burkitt lymphoma has a characteristic "starry-sky" microscopic appearance and is related to a characteristic t(8;14) translocation.

Mantle-cell lymphoma arises from mantle zone B-lymphocytes and has a characteristic t(U;14) translocation.

Marginal zone lymphomas often involve mucosa-associated lymphoid tissue and appear to often begin as reactive polyclonal disorders.

Multiple myeloma is a tumor of plasma cells that is the most common primary tumor arising in the bone of adults and can be associated with production of a monoclonal immunoglobulin spike (M protein) in serum or urine. Monoclonal gammopathy of undetermined significance is the term used when an M protein is found in an asymptomatic individual.

Lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia) is a cross between multiple myeloma and small lymphocytic lymphoma with M spike, but with neoplastic cells that tend to infiltrate many organs and do not cause lytic bone lesions.

Adult T-cell leukemia/lymphoma is a malignant T-cell disorder due to HTLV-1 infection that is found in Japan and the Caribbean.

Mycosis fungoides is a malignant T-cell disorder with a predilection for involving skin. The term sezary syndrome is used if the abnormal lymphocytes are found in the blood and a generalized skin rash is present.

In Hodgkin disease, the malignant cell is the Reed-Sternberg cell, which is positive for CD-15 and CD30. Hodgkin disease is classified into lymphocyte predominant, mixed cellularity, lymphocyte depletion, and nodular sclerosing types. Hodgkin disease has a bimodal age group distribution (late 20s and >50) and usually presents with painless enlargement of lymph nodes.

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