Review Questions

1. A 32-year-old woman comes to the physician because of vaginal bleeding after sexual intercourse. She has also had a foul-smelling vaginal discharge for the past few months. She has not been to the doctor in "ages" and has never had a pelvic examination or a Pap smear. Pelvic examination shows a friable, beefy red cervix. A biopsy is taken and sent to pathology for histologic examination. The results come back as invasive squamous-cell carcinoma. Which of the following viruses is most likely associated with this patient's disease?

A. Epstein-Barr virus

B. Hepatitis B virus

C. Hepatitis C virus

D. Human papilloma virus

E. Human herpes virus 8

; 2. A 43-year-old man comes to the physician because of a "black growth" on his foot. He first noticed this "growth" about 4 months ago, and it has been getting progressively darker and larger. Physical examination shows a 5-cm plaquelike lesion on the sole of his left foot. It is brownish black and has irregular borders. A biopsy is taken from the center of the lesion and is sent to pathology for microscopic evaluation. Which of the following markers will be most helpful in establishing the diagnosis?

A.

CD markers

B.

CA-19-9

C.

CA-125

D.

ER/PR

E.

S100

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