For each patient, select the mechanism of drug action:
a. Inhibition of bacterial cell-wall synthesis b. Lnhi hi tion o f bac te ri al prot ei n > yn I h e si s c. Inhibition of bacterial folic acid synthesis d. Inhibition of bacterial top oisome rase iL (DNA gyrase)
e. Lnhi bi t i on o f bac te ri al DNA po Lym e rase
73, A 39-year-old female with a history of chronic UT1 develops a new infection with Escherichia <:o/i that is sensitive to levofloxacin.
74, A 25-year-old female with a sinus infection caused by Haemophiluss influenzae is treated with tri met ho prim-sulfamethoxazole.
75, A 3 5-year-old male has recently converted to positive on a purified protein derivative of tuberculin (PPD) test for TB. INII is given as prophylaxis.
76, Which of the following may cause damage to growing cartilage?
a. Fluoroquinolones b. Sulfonamides c. Am i n ogl yc osid es d. Cephalosporins e. Tetracyclines
77, À patient with AIDS is treated with a combination of agents, which includes e fa virent. What is the mechanism of action of efavirenz?
a. lnhib iti on o f RNA synthes i s b. Inhibition of DNA synthesis c. Lnhi bi t i on o f vi ra I particle assem bly d. Inhibition of viral proteases e. Inhibition of nucleoside reverse transcriptase f. Lnhi bi t i on of nonnu c L e o si de neverse t ran^ cr ip tase
78, A patient with AIDS is treated with a combination of agents, which includes indinavir. What is the mechanism of action of indinavir?
a. Lnhib iti on o f RN A synthes i s b. Lnhi bi t i on o f DN A sy n i h es i s c. Lnhi bi t i oti o f vi ra 1 particle assem bly d. Inhibition of viral proteases e. Lnhi bi t i on o f n uc L eos i de re ve rs e tr a n se ri p tase f. Inhibition of non nucleoside reverse transcriptase
79, Of the following, the most appropriate statement concerning the reactions caused by aminoglycosides is that these agents a. Produce ototoxicity b Are poient neuromuscular blockers c. Have little or no effect on kidneys d. Produce a high incidence of hypersensitivity reactions similar to those of penicillins e. Produce a high incidence of exfoliative dermatitis
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