Info

This opens the main question about how many of the indicated functions substrates are really relevant in biological cell functions, and three main conclusions can be reached (a) the number of functions, substrates and isoforms, indicates overall that this enzyme family is still a very complex one, requiring a further effort to better understand its biological function most of the reported substrates were identified through in vitro studies only, therefore a more...

Nm004245

Nomenclature Transglutaminase Y, TGY Activated by proteolytic processing. Consists of two polypeptide chains and is synthesized as a precursor form of a single polypeptide. Responsible for the later stages of cell envelope formation in the epidermis and the hair follicle. Transglutaminase Z, TGZ, TGMZ Site of Expression Ubiquitous but predominantly expressed in testis and lung. Also, the transcript level is elevated in breast cancer cells especially in patients with poor prognosis. Fibrin...

Transglutaminase and Cell Survival Signaling

Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A& M University System HSC, College of Medicine, Temple, Tex., USA TGase-2 is a member of the calcium-dependent family of transglutaminases that catalyze post-translational modification of proteins by incorporating polyamines or forming protein cross-links. This transglutaminase activity or transamidation activity involves formation of an isopeptide bond between the 7-carboxamide group of peptide bound glutamine...

Isbn 3805579012

1 Mammalian Transglutaminases A Family Portrait 19 Structure-Function Relationships of Transglutaminases -A Contemporary View Nemes, Z. Csosz, E. Petrovski, G. Fesus, L. (Debrecen) 37 Transglutaminases and Their Substrates Facchiano, F. (Roma) Facchiano, A. (Avellino) 58 Type 2 Transglutaminase and Cell Death Piacentini, M. Amendola, A. Ciccosanti, F. Falasca, L. Farrace, M.G. Mastroberardino, P.G. Nardacci, R. Oliverio, S. Piredda, L. Rodolfo, C. Autuori, F. (Rome) 75 Transglutaminase and...

Transglutaminase Enzyme Increase The Ts In Retanning In Leather

Application of TG2 at cartilage interfaces Increased adhesive strength at cartilage interfaces in vitro Modification of gelatin and collagen Increased proliferation of fibroblasts and differentiation of osteoblasts Scaffolds for wound dressing and tissue repair TGs represent a new class of wound healing mediators. By targeting this group of enzymes, new healing strategies are under development with promising applications in clinics. The use of TGs has been exploited in a number of different...

Transglutaminases and Their Substrates

Francesco Facchianoah, Angelo Facchianoc aDipartimento di Ematologia, Oncolog a e Medicina Molecolare, Istituto Superiore di Sanit , Roma, bLaboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Roma, and cIstituto di Scienze dell'Alimentazione, CNR, Avellino, Italy The family of enzymes called 'Transglutaminase' TGase, EC 2.3.2.13 , represents a fascinating field of study for protein biochemistry researchers. Transglutaminase was described for the first time in 1957...