1. Invasive and uncomfortable
• Hematuria, rectal bleeding, or hematospermia (>50%)
3. Inaccuracies in cancer staging (sensitivity for detection of extra-capsular penetration is around 60%)
4. Imaging prone to artifacts (e.g., secondary to air, calcification, rapid movement)
5. Vasovagal episodes due to vagal nerve stimulation (<5%)
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