Overview

• 99mTc-DMSA has a high affinity for the renal cortex

• 99mTc-DMSA is the preferred radiopharmaceutical for static parenchymal imaging

• Provides the most accurate assessment of relative renal function compared to other tracers

Following tracer injection, 99mTc-DMSA is mostly plasma protein bound, and therefore clearance by GFR is minimal. In the kidney, the cells of the proximal convoluted tubules (and the distal tubules to a lesser extent) extract the 99mTc-DMSA by tubular secretion allowing slow concentration of radioactivity in the renal cortex. After 3 hours, about 50% of the injected tracer is concentrated in the kidneys, remaining there for up to 24 hours. The majority of the other 50% is excreted unchanged in urine. Increased hepatic accumulation, and subsequent biliary excretion is noted in patients in renal failure. Owing to the slow renal extraction of 99mTc-DMSA, the optimal time for imaging is between 2 and 4 hours after tracer injection.

99mTc-DMSA scanning represents functioning tubular mass, yields excellent cortical images, and is an invaluable tool in the assessment of both adults and children.

Was this article helpful?

0 0
Dealing With Erectile Dysfunction

Dealing With Erectile Dysfunction

Whether you call it erectile dysfunction, ED, impotence, or any number of slang terms, erection problems are something many men have to face during the course of their lifetimes.

Get My Free Ebook


Post a comment