Diet and Prostate Cancer Biology
Although prostate cancer is primarily a disease of older men, neoplastic changes may occur in the prostatic epithelium as early as in the third decade. The time required for some of these early neoplastic transformations is likely to be long. Some dietary compounds display antioxi-dant properties, thus preventing peroxidation and generation of free radicals with potential DNA-damaging effects. Others are inhibitors of cell proliferation, apoptosis inducers, or enhancers of cellular differentiation. Some may act at a hormonal level, as the prostate is an androgen-regulated organ. In many cases, though, the precise pathways modulated by these compounds and mechanisms of DNA damage induced by carcinogenic agents are still poorly understood.
Urological Cancers: Science and Treatment