Peripheral Vascular Surgery and Statins

Graft patency and limb salvage were improved in patients taking statins before infra-inguinal by-pass surgery [18].

Aggressive lipid lowering may reduce the high mortality and morbidity (mainly from coronary events) associated with vascular surgery in PAD and other patients [14, 29]. Coronary events are the most important cause of long-term morbidity and mortality after peripheral vascular surgery [12, 14]. Even PAD patients without overt CHD are at significant risk of long-term cardiac events.

The effect of atorvastatin compared with placebo on the occurrence of a composite of cardiovascular events after vascular surgery was assessed [12]. Patients (n = 100) were randomly assigned to atorvastatin 20 mg once daily (n = 50) or placebo (n = 50) for 45 days, irrespective of their serum cholesterol concentration. Vascular surgery was performed on average 30 days after randomization. During the 6-month follow-up, the incidence of cardiac events was higher in the placebo compared with the ator-vastatin group [13 (26.0%) versus 4 (8.0%); p = 0.031].

In a case-control study, among patients (n = 2816) who underwent major vascular surgery, 160 (5.7%) died during their hospital stay [32]. After adjustments, statin therapy was significantly less common in the patients who died than in controls (8% versus 25%; p < 0.001). The adjusted OR for peri-operative mortality among statin users as compared with nonusers was 0.22 (95% CI = 0.10-0.47).

Lower Your Cholesterol In Just 33 Days

Lower Your Cholesterol In Just 33 Days

Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!

Get My Free Ebook

Post a comment