A post-hoc analysis of the Scandinavian Simvastatin Survival Study (4S) found that new or worsening intermittent claudication was significantly (p = 0.008) reduced (by 38%) in those taking the statin when compared with the group assigned to placebo . All the patients (n = 4444) participating in this trial had CHD and were fol-lowed-up for a median of 5.4 years.
In the Program on the Surgical Control of Hyperlipid-emias (POSCH)  the effect of cholesterol-lowering induced by partial ileal by-pass in patients (n = 838) with a previous MI and hyperlipidaemia was assessed. The incidence of new cases of claudication was significantly lower [relative risk (RR): 0.66, 95% confidence interval (CI): 0.20-0.90; p = 0.009] in the intervention group when compared with the control (nonintervention) group 4 years after the closure of the trial.
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