Transient Reversible Cerebral Ischaemia

Its clinical manifestations result from neurological dysfunction in the territory of the internal carotid artery and its main branches, the anterior and middle cerebral arteries. They can be:

• Transient (TIAs), when lasting less than 24 h with full recovery.

• Reversible, when the symptoms disappear after 24 h without neurological deficit. Symptoms depend upon the involved area, giving rise to contralateral motor and/or sensory deficit. Dysphasia/aphasia may also arise following dominant hemisphere lesions.

• Crescendo TIAs, characterized by a succession of TIAs in a short period of time which could correspond to multiple embolization from active carotid plaques carrying an increased risk of permanent neurological deficit.

Fig. 2.2.3 Histologic examination of a carotid plaque removed by endarterectomy with cholesterol crystals surrounded by inflammatory infiltrate

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Diabetes 2

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