The accuracy of a diagnostic tool can vary with the prevalence of a disease or disorder. This may apply for the accuracy of both display methods as well. As a consequence a differentiation between high and low prevalence studies is made in this paragraph.
The sensitivity per polyp is used as a criterion for the functioning of the review methods different diagnostic modes, since it is a more precise way to measure the visibility of a polyp. However, in a screening setting the sensitivity per patient is a more important outcome parameter since the consequence of a positive colonography will be a referral for colonoscopy.
In this paragraph both primary 2D and primary 3D are described. It is likely that in primary 2D the combination with 3D problem solving will reduce the amount of false positive findings compared to 2D reviewing only; Cotton et al. (2004) who used a 2D method combined with 3D for problem solving in only a part of the patients described an increase in correct lesion identifications when the 3D method was used, McFarland et al. (2001) stated that in individual cases the added value of 3D was anecdotal.
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