The diagnostic performance in a screening cohort might be poorer than in a cohort with a high prevalence of disease. It is useful to know what percentage of cases are truly screening, meaning average risk for colorectal cancer (CRC), the risk factor being age 50 years or older, vs above average risk patients. Above average risk patients are those with a family history of CRC (particularly in a first degree relative), a personal history of CRC or colonic adenomas, or signs or symptoms suggestive of a colonic abnormality (e.g. blood in the stool, weight loss, anemia, etc.).
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