A

Replicase Motifs

A Polymerase (GDD)

I Helicase

Coding Domains

Nonstructural proteins

Structural proteins Poly(C) tract

0 Vpg

FIGURE 3.2 (A) Genome organization of poliovirus showing the proteolytic processing steps. Both the 3Cpro and 2Apro proteases are "serine-like proteases" with cysteine in the catalytic site. (B) Comparative genome organizations of representatives of seven of the nine genera of Picornaviridae. [Adapted from Murphy et al. (1995, p. 300) and Yamashita et al. (1998).]

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