Npn

Icosahedral symmetry adenoviruses, 42 alphaviruses, 46-47 atomic structures, 37-38 blue tongue virus, 40-42 description, 35-37 enveloped viruses, 43-45 nonenveloped viruses, 42-43 nucleocapsids, 47-48 polyomaviruses, 39-40 pseudo T=3 viruses, 37-38 T=3 viruses, 37 virus comparisons, 37 ICTV. see International Committee on

Taxonomy of Viruses IFNs. see Interferons

Immune system. see also specific components adaptive

B cells, 311, 314-315 control of virus infection, 318 CTLs, 307-310 MHC

description, 303-307 interference, 334-336 T-helper cells, 311 compromised, effects of EBV, 250 HBV and, 216-217 innate, 323-324 response, components, 303 vector systems and, 357-358 viral circumvention of, tactics apoptosis inhibition, 338 Bcl-2 homolog production, 339-440 chemokine activity disruption, 341-342 in complement system, 317-318 cytokine activity disruption, 341-342 effector cell infection, 337-338 evasion of antiviral state, 342-343 evolution, 332, 334 Fas signaling interference, 338 IFN signaling interference, 343 latent infections, 337 MHC I interference, 334-336 NK cells activity interference, 338 rapid drift, 338 rapid growth, 334 serpin production, 338 TNF signaling interference, 338 virokines secretion, 345 Immunoglobulins

Burkitt's lymphoma, 249 classifications, 311-312 heavy chain formation, 312-314 IgA, function, 316 IgD, function, 316-317 IgE, function, 316

IgG, function, 316 IgG, protein A binding to, 352 light chain formation, 312-314 production, 315-317 Indiana vesiculovirus, 129 Infections chronic, 28 congenital, 30 control of, 318 death rate, decline, 1-2 latent, 337 lytic, 27-28 Influenza viruses classification, 147-148 DIs, 281-282 glycoproteins, 149 mRNA 5' extensions, 20 neuraminidase in, 46 proteins encoded by, 148-149 rapid drift, 338 receptor, characterization, 11 type A

antigenic shift/drift, 155 associated illnesses, 151-152 epidemics of, 151 natural history, 151 pandemic of 1918, 153-156 vaccination, 155-156 typeB, 156 type C

description, 102 glycoproteins, 149 infections, 156 virions assembly, 150-151 Integrase, 174 Interferons activity, viral neutralization, 344-345 antiviral state, 331-332 biological effects, 330-331 characterization, 326 effect on mRNA translation, 332 functions, 326 genes induced by, 331-332 induction, 327-329 receptors, 329-330 signal transduction response, 329-330 viral interference, 343 therapeutic use, 332 types, 326-327 Interferon stimulated response element, 354 Interleukin activity, viral neutralization,

344-345 Internal ribosome entry sites description, 25 EMC's, usefulness, 68 International Committee on Taxonomy of

Viruses, 6-8 Intracellular proteins, 240 IRES. see Internal ribosome entry site ISRE. see Interferon stimulated response element

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