Info

I Elongation through hairpin

I Elongation through hairpin

Nick at arrowhead to start second round ->

Simple concatemer formation

FIGURE 6.3 Model for the replication of orthopox DNA. Replication is initiated by nicking one strand at the red arrow near the left end of the DNA. This is followed by primer extension and loopback to form an internal primer. Extension then occurs through the hairpin at the right end of the molecule to form a concatemer. Concatemer resolution occurs by nicking at the blue arrows. Parental DNA is shown in blue, new strands in red. [Redrawn from data in Moyer and Graves (1981) and Traktman (1990).]

Nick at arrowhead to start second round ->

Complex Concatemers

Simple concatemer formation d c b a

Was this article helpful?

0 0

Post a comment