P

Burkitt's lymphoma, 249 cell cycle regulation by, 268 concentrations control of, 340-341 T antigen binding to, 260 p80, 98 P123, 76, 77 p125, 98

Papain-like proteases, 27 Papillomaviruses. see also specific viruses characterization, 259, 265 classification, 259 DNA replication, 261 early genes, 259-260 human, 264-265 infection, 265 mRNA transcription, 266 target proteins, 256 transforming genes, 266, 268 Parainfluenza viruses, 135-137 Paramyxoviruses. see also specific viruses emerging, 142-143 genus, 132-132 glycoproteins, 134—135 neuraminidase in, 46 replication, 133 SV-5, glycoproteins, 149 Parvoviruses. see also specific viruses characterization, 270, 275-276 replication, 270-271 transcription, 270 virion structure, 271 PEG. see Polyethylene glycol Peripheral blood mononuclear cells, 147 Pestiviruses, 98-99 P gene, 135

Phleboviruses, 160. see also specific viruses Phosphoprotein, 124-125 Picornaviruses. see also specific viruses formation, 53 genome expression, 59-62 nomenclature, 58-59 organization, 69-62 protein functions, 62 proteins, 62 replication, 62 PIVs. see Parainfluenza viruses Plant viruses. see also specific viruses penetration, 12-14 satellites, 283-284 PMBC. see Peripheral blood mononuclear cells PML. see Progressive multifocal leukoencephalopathy Pneumonia, influenza A virus-induced, 151-152 Pneumovirus, 143 Podospora prions, 300-302 Poliomyelitis characterization, 63 eradication, 65 vaccine development, 63-64 Polioviruses. see also specific viruses associated disease, 63 atomic structure, 37-39 eradication, 65 genome expression, 59-62

Polioviruses (continued) organization, 59-62 screening for, 65, 67 second protease, 61-62 type 3, 319 vaccine, 265

vector development, 352-354 virion stability, 55 Poliovirus receptor. see CD155 Pol polyproteins capsid formation, 189 processing protease, 27 in retrovirus vectors, 349-350 in spumaviruses, 206 Poly(A) retrotransposons, 209 Polyarthritis, 82-83 Polyethylene glycol, 362 Polyomaviruses. see also specific viruses atomic structure, 39-40 classification, 259 target proteins, 256 Polyprotein processing, 25-27 Polypurine tract description, 175 Porcine reproductive and respiratory syndrome virus, 104

Post-transciptional regulatory element, 212 Powassan viruses, 95-96 Poxviruses. see also specific viruses apoptosis inhibition, 341 characterization, 223 cytokine-binding protein production by,

344-345 envelopes, 50 host range, 223 -hosts, interaction, 226, 228 immune system evasion tactics, 324-325 replication, 14-15, 225-226 virion structure, 223, 225 PPT. see Polypurine tract

PRE. see Post-transciptional regulatory element Primate T-lymphotropic viruses. see also specific viruses accessory genes, 185-186 associated diseases, 194-195 discovery, 171 unspliced RNA, 187-188 Prion diseases associated protein characterization, 297-298 ex vivo and in vitro studies, 298-299 mouse studies, 298 role in disease, 299-300 transport to brain, 299-300 description, 291 types animal forms, 293-294 CJD, 292-293, 295-297 kuru, 291-292 Prions, yeast, 300-302 Programmed cell death. see Apoptosis Progressive multifocal leukoencephalopathy,

264-265 Pro polyproteins capsid formation, 189

characterization, 20-21 processing, 180-182 retroviruses encoding, 174 Prospect Hill virus, 160 Protease inhibitors, 201, 203 Proteases aspartate, 27 metalloprotease, 27 papain-like, 27 serine, 26-27 Protein kinase R

activation, viral interference, 342-343 characterization, 332 PRRSV see Porcine reproductive and respiratory syndrome virus PTLV. see Primate T-lymphotropic viruses

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