Although common on the skin, basal cell carcinoma of the vulva represents only about 2% to 3% of vulvar carcinomas (Fig. 35) (64). These tend to be locally invasive lesions, but can rarely metastasize, particularly if associated with more aggressive histologic subtypes, including basosquamous, morpheaform, metatypical, or micro-nodular (65,66). Vulvar basal cell carcinomas usually occur on the labia majora, and are most often found in Caucasian women 70 years of age and older (66). Diagnosis is often late because of lack of symptoms. The tumor suppressor protein P16, over-expressed by HPV, has been detected immunohistochemically in some cases (Table 35) (67).
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.