V ,■ ■ . n i 7 nil T 1^1 ilrTOtiBM

Figure 6.29 Vulvar intraepithelial neoplasia. (VIN), usual type. (A) This VIN lesion is pigmented. (B) This is an example of a depigmented VIN lesion. (C) In the warty pattern, cytopathic features of human papilloma virus are prominent. (See p. 160)

Figure 6.30 Differentiated vulvar intraepithelial neoplasia. (VIN). (B) The cells show glassy eosinophilic cytoplasm, pronounced cell borders, and prominent nucleoli. There is a keratin pearl in the left upper portion of the field. (See p. 161)

Figure 6.31 (A) Paget's disease: the lesions are red and velvety, with white patches. (B) The typical large Paget cells contain abundant pale cytoplasm and are seen at the dermal-epidermal junction, as well as percolating up the epithelium. (See p. 162)

Figure 6.32 Squamous cell carcinoma of the vulva. (B) This is an example of an endophytic lesion. (See p. 163)

Figure 6.34 Melanoma. (B) The lesion is often composed of epithelioid cells with prominent nucleoli. Melanin pigment may be present or not. Melanomas may mimic a variety of neoplasms, and a variety of stains are available to confirm the nature of the lesion. (See p. 165)

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