Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma protuberans (DFSP) is a low-grade malignancy normally seen in subcutaneous tissues (Fig. 38A and B). It rarely involves the vulva. It tends to recur after excision but rarely metastasizes (70), although the rare development of fibrosarcoma has been described (71). Histologically, DFSP is composed of bland spindle cells that stain for CD34. It often extends beyond the obvious gross borders in small projections, which is probably contributory to the recurrences (Table 38).

Figure 36 Lymphoepithelial carcinoma: a mix of neoplastic glassy epithelioid cells and lymphocytes is seen.
Table 36 Lymphoepithelioma-Like Carcinoma

Clinical

Differential

Diagnosis

Symptoms

appearance

diagnosis

Therapy

Lymphoepithelioma-

Mass

Mass

Lymphoma

Surgical

like carcinoma

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