Embryologic homologies and empiric use led to the advocacy of topical androgens for LS. Long clinical experience and anecdotal reports attest to the popularity and apparent success of topical testosterone in the treatment of LS (9,18-21) and there are a few patients whose successful treatment has included low-dose oral testosterone. But, with the advent of the very potent topical corticosteroid, clobetasol, and with reports of its effectiveness (20), topical testosterone has little or no support in recent publications (21-23), but should not be dismissed. An appropriate clinical study to evaluate the efficacy of topical testosterone would be difficult to mount: withholding clobetasol would not be appropriate, but the criteria for determining the benefit of both agents together as opposed to the corticosteroid alone would be hard to construct (23).
Vitamin A, formerly, and the oral retinoid, acitretin, recently, have also been advocated in the treatment of LS and the latter may interact with nuclear receptors to alter gene expression (24).
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.