Anti Obesity Drugs

Apart from diet, combination with pharmacological treatment with metformin or with weight-reducing agents has been used when required for further weight reduction. It has been reported that the combination of a low-calorie diet with metformin treatment induced greater reduction of body weight and visceral obesity in women with PCOS compared with a low-calorie diet and placebo treatment (136). Weight-reducing agents have been shown to increase the effect of lifestyle modification in reducing the incidence of type 2 diabetes in obese patients (137), and similar effects have been noted in women with PCOS. Sibutramine treatment alone and in combination with ethinyl estradiol and cyproterone acetate in obese women with PCOS has been found to have positive effects on clinical and metabolic risk factors for cardiovascular disease (decrease in waist-to-hip ratio, blood pressure, triglycerides, and insulin levels) (138). Furthermore, orlistat treatment in obese women with PCOS induced a more significant weight reduction than metformin treatment. It also induced a reduction of testosterone levels, which is consistent with the reduction of testosterone levels in overweight women with PCOS after weight loss by dietary changes and exercise (139). However, it is difficult to assess the long-term clinical efficiency of the medications because the literature is rather inconclusive (small number of patients and short-term studies). Common side effects (headache, insomnia) and potentially serious cardiovascular effects (hypertension, arrythmias, etc.) limit the widespread use of sibutramine, and although orlistat generally has a safer side-effect profile, the frequent adverse effects on bowel habits (flatulence, steatorrhea, GI discomfort) are also significant hurdles to its use.

Gaining Weight 101

Gaining Weight 101

Find out why long exhausting workouts may do more harm than good. Most of the body-building workout and diet regimens out there are designed for the guys that gain muscle and fat easily. They focus on eating less and working out more in order to cut the excess fat from their bodies while adding needed muscle tone.

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