Endocannabinoids And Regulation Of Energy Balance

Early animal studies demonstrated that systemic or oral administration of A9-THC potently increases food intake. Administration of CB1 antagonists, conversely, blocks the orexigenic action of exogenous cannabinoid agonists and also decreases food intake and body weight in laboratory animals (reviewed in ref. 16). Based on these promising observations, considerable research is currently under way to elucidate the mechanisms of action of endocannabinoids and to determine the feasibility of using cannabinoid antagonists to treat obesity and its complications (48,49).

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