Mesoderm

Mesoderm gives further rise to paraxial mesoderm (35 pairs of somites), intermediate mesoderm, and lateral mesoderm.

Clinical Correlate

Caudal Dysplasia (Sirenomelia) Caudal dysplasia refers to a constellation of syndromes ranging from minor lesions of the lower vertebrae to complete fusion of lower limbs as a result of abnormal gastrulation in which migration of mesoderm is disturbed. It is associated with VATER (vertebral defects, anal atresia, tracheoesophageal fistula, and renal defects) or VACTERL (vertebral defects, anal atresia, cardiovascular defects, tracheo esophageal fistula, renal defects, and upper limb defects).

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