Nephron

The nephron consists of a renal corpuscle, proximal convoluted tubule, loop of Henle, and distal convoluted tubule (Figure 1-8-2).

Figure 1-8-2. Nephron Diagram

Renal corpuscle

The renal corpuscle consists of a tuft of capillaries, or glomerulus, surrounded by a doublewalled epithelial capsule called Bowman capsule (Figure 1-8-3).

Glomerulus

The glomerulus is composed of several_anastomotic capillary loops interposed between an afferent and an efferent arteriole. The endothelium of the glomerulus is thin and fenestrated. Plasma filtration (ultrafiltration) occurs in the glomerulus.

Bowman Capsule

The Bowman capsule consists of an inner visceral layer and an outer parietal layer (Figure 1-8-3). The space between these layers, the urinary space, is continuous with the renal tubule.

■ The visceral layer is composed of podocytes resting on a basal lamina, which is fused with the basal lamina of the capillary endothelium (Figures 1-8-4,1-8-5, and 1-8-6).

• The parietal layer is composed of a simple squamous epithelium that is continuous with the proximal convoluted tubule epithelial lining.

Parietal layer

Urinary space

Afferent arteriole

Visceral layer (Podocytes)

Efferent arteriole

Area of detail

Podocyte Foot processes

Figure 1-8-3. Bowman Capsule Diagram

Podocyte Foot processes

Efferent arteriole

Parietal layer

Urinary space

Fenestrated Basal lamina

Afferent arteriole

Area of detail

Visceral layer (Podocytes)

Figure 1-8-3. Bowman Capsule Diagram

KAPLAWL. -

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