Fast Pregnancy Sickness Cure
In the case of Changshan, it is not resistance that has been the problem leading to disuse of the drug, as we have seen, but nausea and vomiting associated with the known emetic effects of febrifugine. Not surprisingly, however, at least three of the other ingredients in the classical formulation studied in China in the mid-20th century would seem to be candidates for offsetting the emetic properties of Changshan. They are Zingiber officinale (ginger), Glycyrrhiza glabra (liquorice), and Areca catechu (betel nut). Zingiber officinale, ginger, is an ingredient in the classical formula and has been found through a large body of experimental and clinical research to be effective against nausea. A systematic review of the evidence from randomised controlled trials (RCTs) of ginger for nausea and vomiting found that six studies met all inclusion criteria. Of three RCTs on postoperative nausea and vomiting, two suggested that ginger was superior to placebo and as effective as...
Derivative that was initially used for morning sickness but was taken off the market due to ter-atogenicity and neuropathies. Thalidomide has antiangiogenesis effects, inhibits cytokines including tumor necrosis factor-a, and can alter cell adhesion molecules. In a randomized phase II trial with 75 HRPC patients, comparing thalidomide and docetaxel with docetaxel alone, Leonard et al 55 reported a PSA response rate of 50 , and an increase in median survival by 14 months. Gastrointestinal, neurological, and thromboembolic toxicities were reported, the latter necessitating the use of prophylactic anticoagulation. Larger trials incorporating palliative end points, and more data on toxicity are needed to determine whether this combination is a viable option in HRPC.
As noted in Table 4.1, there are many classical antifebrile formulations containing Changshan other than that used to cure Mrs. Chu. One simple formula that is currently under study (Jiang, 2003) adds cardamom seeds to D. febrifuga to offset nausea. The seeds of two species of cardamom have been used traditionally Both A. tsaoko and A. vilosum are used in the treatment of abdominal pain and congestion, lack of appetite, nausea, and vomiting. A. tsaoko has also been used to treat malarial patients (Li, 1593 Yao et al., 1995). A. vilosum was used in classical Chinese medicine to treat nausea and vomiting, abdominal pain, diarrhoea, indigestion, gas, loss of appetite, morning sickness, pain and discomfort during pregnancy, and involuntary urination (Time-Life, 1997). Clearly there are a range of options open to researchers seeking a traditional source for the management of nausea associated with D. febrifuga and its derivatives.
Some women get a little morning sickness, swelling of the breasts, or other signs of pregnancy when they first start taking the pill. This is because the pill contains the same chemicals (hormones) that a woman's body puts into her blood when she is pregnant. These signs do not mean she is unhealthy or should stop taking the pill. They usually go away after the first 2 or 3 months. If the signs do not go away, she may need to change to a kind with a different amount of hormone. This is discussed in the GREEN PAGES (p. 394 and 395).