The reproducibility and predictability of tumorigenicity in transgenic mice are allowing the different stages in tumorigenesis to be studied using the powerful tool of reverse genetics in the whole organism. By using transgenic animals, the role of specific oncogenes and tumor progression factors is being directly analyzed with a new precision. Transgenic models of particular cancers offer the promise of a better understanding of the process of tumor progression, with a consequent improvement in therapeutic approaches to the human disease.

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