Many of the procedures described in the present volume are the subject of governmental regulation. Investigators should consult the appropriate local authorities before embarking on any study involving animal experimentation and/or genetic engineering. Researchers must always consider the fundamental principle of ethical research (2), which is that experimental animals must not be subjected to avoidable distress or discomfort. Research animals should be acquired and cared for in accordance with standards established by the National Institutes of Health (3).
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