Chromosomal Alterations

Up to 54% of primary cancers and 100% of metastatic tumors have LOH occurring in at least one chromosome. The technique of comparative genomic hybridization (CGH) has helped to identify the most commonly altered chromosomal regions in prostate cancer. Chromosomal losses are far more common that gains in primary tumors; however, they are found at equal frequencies in hormone-refractory tumors [10]. This suggests that tumor suppressor inacti-vation may be an early event in prostate cancer

The Molecular Biology of Prostate Cancer

Normal prostate gland

Hereditary factors Hormonal factors Receptor polymorphisms

Intraepithelial neoplasia

Early oncogene activation and loss of tumors suppressor genes (e.g., Rb)

Prostate carcinoma

Late oncogene activation and loss of tumor suppressor genes (e.g.,p53, ras)

20%. In metastatic or treatment-resistant disease, however, the incidence reaches 50% to 75% [17]. This suggests that mutations of the p53 gene are a late development in prostate cancer progression.

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